Pretomanid
Pretomanid is a nitroimidazooxazine antimycobacterial agent that is activated by the deazaflavin-dependent nitroreductase (Ddn) of Mycobacterium tuberculosis, producing reactive nitrogen and carbon-based radicals that inhibit mycolic acid biosynthesis and cause cell death under both aerobic and anaerobic conditions. It is used in combination with bedaquiline and linezolid for the treatment of extensively drug-resistant (XDR) and treatment-intolerant or non-responsive multidrug-resistant tuberculosis.
分子量
359.2600 g/mol
LogP
2.80
TPSA
91.30 Ų
Lipinski 五规则
符合
治疗领域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
O=[N+]([O-])c1cn2c(n1)OC[C@@H](OCc1ccc(OC(F)(F)F)cc1)C2
InChI
InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
Molecular Formula
C14H12F3N3O5
HBD / HBA
- / 9
可旋转键数
4
重原子数
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Pretomanid is a nitroimidazooxazine antimycobacterial agent that is activated by the deazaflavin-dependent nitroreductase (Ddn) of Mycobacterium tuberculosis, producing reactive nitrogen and carbon-based radicals that inhibit mycolic acid biosynthesis and cause cell death under both aerobic and anaerobic conditions. It is used in combination with bedaquiline and linezolid for the treatment of extensively drug-resistant (XDR) and treatment-intolerant or non-responsive multidrug-resistant tuberculosis.
Yes, Pretomanid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL227875. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 456199. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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