Siponimod
Siponimod is a selective sphingosine-1-phosphate receptor modulator (S1P1 and S1P5) used for the treatment of active secondary progressive multiple sclerosis (SPMS). By binding to S1P1 receptors on lymphocytes, it causes their sequestration in lymph nodes, reducing pathogenic lymphocyte migration into the CNS and associated neuroinflammation and demyelination. Its selectivity for S1P5, expressed on oligodendrocytes and NK cells, may provide additional neuroprotective effects relevant to SPMS progression.
分子量
516.6000 g/mol
LogP
4.80
TPSA
62.10 Ų
Lipinski 五规则
符合
治疗领域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
CCc1cc(/C(C)=N/OCc2ccc(C3CCCCC3)c(C(F)(F)F)c2)ccc1CN1CC(C(=O)O)C1
InChI
InChI=1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30,31)32/h9-14,22,25H,3-8,15-18H2,1-2H3,(H,35,36)/b33-19+
Molecular Formula
C29H35F3N2O3
HBD / HBA
1 / 8
可旋转键数
9
重原子数
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Siponimod is a selective sphingosine-1-phosphate receptor modulator (S1P1 and S1P5) used for the treatment of active secondary progressive multiple sclerosis (SPMS). By binding to S1P1 receptors on lymphocytes, it causes their sequestration in lymph nodes, reducing pathogenic lymphocyte migration into the CNS and associated neuroinflammation and demyelination. Its selectivity for S1P5, expressed on oligodendrocytes and NK cells, may provide additional neuroprotective effects relevant to SPMS progression.
Yes, Siponimod is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2336071. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 44599207. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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