Siponimod
Siponimod is a selective sphingosine-1-phosphate receptor modulator (S1P1 and S1P5) used for the treatment of active secondary progressive multiple sclerosis (SPMS). By binding to S1P1 receptors on lymphocytes, it causes their sequestration in lymph nodes, reducing pathogenic lymphocyte migration into the CNS and associated neuroinflammation and demyelination. Its selectivity for S1P5, expressed on oligodendrocytes and NK cells, may provide additional neuroprotective effects relevant to SPMS progression.
Molecular Weight
516.6000 g/mol
LogP
4.80
TPSA
62.10 Ų
Lipinski RO5
Pass
Therapeutic Areas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
CCc1cc(/C(C)=N/OCc2ccc(C3CCCCC3)c(C(F)(F)F)c2)ccc1CN1CC(C(=O)O)C1
InChI
InChI=1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30,31)32/h9-14,22,25H,3-8,15-18H2,1-2H3,(H,35,36)/b33-19+
Molecular Formula
C29H35F3N2O3
HBD / HBA
1 / 8
Rotatable Bonds
9
Heavy Atoms
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Siponimod is a selective sphingosine-1-phosphate receptor modulator (S1P1 and S1P5) used for the treatment of active secondary progressive multiple sclerosis (SPMS). By binding to S1P1 receptors on lymphocytes, it causes their sequestration in lymph nodes, reducing pathogenic lymphocyte migration into the CNS and associated neuroinflammation and demyelination. Its selectivity for S1P5, expressed on oligodendrocytes and NK cells, may provide additional neuroprotective effects relevant to SPMS progression.
Yes, Siponimod is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2336071. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 44599207. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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