Sulfabenzamide
Sulfabenzamide is a sulfonamide antibiotic used as a component of triple sulfonamide vaginal cream formulations for the treatment of Haemophilus vaginalis (Gardnerella) vaginitis and other vaginal infections caused by susceptible bacteria. Like all sulfonamides, it inhibits bacterial dihydropteroate synthase, blocking folic acid synthesis required for bacterial nucleotide production. It is typically combined with sulfacetamide and sulfathiazole for broader antibacterial coverage in vaginal infections.
分子量
276.3100 g/mol
LogP
0.70
TPSA
97.60 Ų
Lipinski 五规则
符合
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
Nc1ccc(S(=O)(=O)NC(=O)c2ccccc2)cc1
InChI
InChI=1S/C13H12N2O3S/c14-11-6-8-12(9-7-11)19(17,18)15-13(16)10-4-2-1-3-5-10/h1-9H,14H2,(H,15,16)
Molecular Formula
C13H12N2O3S
HBD / HBA
2 / 4
可旋转键数
3
重原子数
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Sulfabenzamide is a sulfonamide antibiotic used as a component of triple sulfonamide vaginal cream formulations for the treatment of Haemophilus vaginalis (Gardnerella) vaginitis and other vaginal infections caused by susceptible bacteria. Like all sulfonamides, it inhibits bacterial dihydropteroate synthase, blocking folic acid synthesis required for bacterial nucleotide production. It is typically combined with sulfacetamide and sulfathiazole for broader antibacterial coverage in vaginal infections.
Yes, Sulfabenzamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1243. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5319. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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