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Sulfabenzamide

CHEMBL1243 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
276.3 g/mol
LogP
0.7
Phase
4

Sulfabenzamide is a sulfonamide antibiotic used as a component of triple sulfonamide vaginal cream formulations for the treatment of Haemophilus vaginalis (Gardnerella) vaginitis and other vaginal infections caused by susceptible bacteria. Like all sulfonamides, it inhibits bacterial dihydropteroate synthase, blocking folic acid synthesis required for bacterial nucleotide production. It is typically combined with sulfacetamide and sulfathiazole for broader antibacterial coverage in vaginal infections.

Molecular Weight

276.3100 g/mol

LogP

0.70

TPSA

97.60 Ų

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Nc1ccc(S(=O)(=O)NC(=O)c2ccccc2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C13H12N2O3S/c14-11-6-8-12(9-7-11)19(17,18)15-13(16)10-4-2-1-3-5-10/h1-9H,14H2,(H,15,16)

                

                

                

                    
                    

                        
Molecular Formula

                        
C13H12N2O3S

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
Rotatable Bonds

                        
3

                    

                    
                    
                    

                        
Heavy Atoms

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
Sulfabenzamide is a sulfonamide antibiotic used as a component of triple sulfonamide vaginal cream formulations for the treatment of Haemophilus vaginalis (Gardnerella) vaginitis and other vaginal infections caused by susceptible bacteria. Like all sulfonamides, it inhibits bacterial dihydropteroate synthase, blocking folic acid synthesis required for bacterial nucleotide production. It is typically combined with sulfacetamide and sulfathiazole for broader antibacterial coverage in vaginal infections.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Sulfabenzamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1243.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5319.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.