Sulfasalazine
Taken orally, this anti-inflammatory medication releases two active components in the colon — sulfapyridine and mesalazine — where they reduce the chronic inflammation driving conditions like Crohn's disease, ulcerative colitis, and rheumatoid arthritis. It is also being investigated for potential effects in certain cancers due to its ability to interfere with inflammatory signaling pathways.
分子量
398.4000 g/mol
LogP
-0.70
TPSA
150.00 Ų
Lipinski 五规则
符合
治疗领域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
O=C(O)c1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O
InChI
InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
Molecular Formula
C18H14N4O5S
HBD / HBA
3 / 9
可旋转键数
6
重原子数
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Taken orally, this anti-inflammatory medication releases two active components in the colon — sulfapyridine and mesalazine — where they reduce the chronic inflammation driving conditions like Crohn's disease, ulcerative colitis, and rheumatoid arthritis. It is also being investigated for potential effects in certain cancers due to its ability to interfere with inflammatory signaling pathways.
Yes, Sulfasalazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL421. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5339. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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