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Sulfasalazine

CHEMBL421 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
398.4 g/mol
LogP
-0.7
Phase
4

Taken orally, this anti-inflammatory medication releases two active components in the colon — sulfapyridine and mesalazine — where they reduce the chronic inflammation driving conditions like Crohn's disease, ulcerative colitis, and rheumatoid arthritis. It is also being investigated for potential effects in certain cancers due to its ability to interfere with inflammatory signaling pathways.

Khối lượng phân tử

398,4000 g/mol

LogP

-0,70

TPSA

150,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Age-Related Macular Degeneration Respiratory Disease Rheumatoid Arthritis Migraine Generalized Anxiety Disorder Inflammatory Bowel Disease Psoriasis Systemic Lupus Erythematosus Lymphoma Transplant Medicine Type 2 Diabetes Hypertension Breast Cancer Chronic Pain Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=C(O)c1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O

                

                

                
                

                    
InChI

                    
InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H14N4O5S

                    

                    
                    

                        
HBD / HBA

                        
3 / 9

                    

                    
                    

                        
Liên kết có thể quay

                        
6

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
28

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Taken orally, this anti-inflammatory medication releases two active components in the colon — sulfapyridine and mesalazine — where they reduce the chronic inflammation driving conditions like Crohn's disease, ulcerative colitis, and rheumatoid arthritis. It is also being investigated for potential effects in certain cancers due to its ability to interfere with inflammatory signaling pathways.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Sulfasalazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL421.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5339.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.