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Suvorexant

CHEMBL1083659 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
450.9 g/mol
LogP
4.9
Phase
4

Rather than sedating the brain broadly, this medication blocks orexin receptors — the wake-promoting signaling system — to allow natural sleep to occur without forcing sedation. It is used for insomnia in adults and is also being studied for its potential to improve sleep quality in patients with Alzheimer's disease.

分子量

450.9000 g/mol

LogP

4.90

TPSA

80.30 Ų

Lipinski 五规则

符合

治疗领域

Bipolar Disorder Generalized Anxiety Disorder Insomnia Multiple Sclerosis Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cc1ccc(-n2nccn2)c(C(=O)N2CCN(c3nc4cc(Cl)ccc4o3)CC[C@H]2C)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C23H23ClN6O2/c1-15-3-5-20(30-25-8-9-26-30)18(13-15)22(31)29-12-11-28(10-7-16(29)2)23-27-19-14-17(24)4-6-21(19)32-23/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3/t16-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C23H23ClN6O2

                    

                    
                    

                        
HBD / HBA

                        
- / 6

                    

                    
                    

                        
可旋转键数

                        
3

                    

                    
                    
                    

                        
重原子数

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
Rather than sedating the brain broadly, this medication blocks orexin receptors — the wake-promoting signaling system — to allow natural sleep to occur without forcing sedation. It is used for insomnia in adults and is also being studied for its potential to improve sleep quality in patients with Alzheimer's disease.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Suvorexant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1083659.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 24965990.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.