Suxibuzone
Suxibuzone is a prodrug of phenylbutazone, a pyrazolidine-class NSAID, which is hydrolyzed in the body to the active metabolite phenylbutazone and ketobutazone, used for anti-inflammatory and analgesic treatment of musculoskeletal conditions and arthritis. The prodrug form was developed to reduce the gastrointestinal irritation associated with phenylbutazone by providing slower release of the active drug. Like phenylbutazone, it inhibits cyclooxygenase enzymes and has additional effects on leukocyte migration.
分子量
438.5000 g/mol
LogP
3.60
TPSA
104.00 Ų
Lipinski 五规则
符合
作用机制
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
二维结构
Cite this structure
Embed this structure
SMILES
CCCCC1(COC(=O)CCC(=O)O)C(=O)N(c2ccccc2)N(c2ccccc2)C1=O
InChI
InChI=1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)
Molecular Formula
C24H26N2O6
HBD / HBA
1 / 6
可旋转键数
11
重原子数
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Suxibuzone is a prodrug of phenylbutazone, a pyrazolidine-class NSAID, which is hydrolyzed in the body to the active metabolite phenylbutazone and ketobutazone, used for anti-inflammatory and analgesic treatment of musculoskeletal conditions and arthritis. The prodrug form was developed to reduce the gastrointestinal irritation associated with phenylbutazone by providing slower release of the active drug. Like phenylbutazone, it inhibits cyclooxygenase enzymes and has additional effects on leukocyte migration.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Suxibuzone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1414320. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5362. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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