Tolbutamide

CHEMBL782 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

270.4 g/mol

LogP

2.3

Phase

4

This oral sulfonylurea medication stimulates the pancreas to produce more insulin and is used to lower blood sugar in adults with type 2 diabetes. It is an older drug largely replaced by newer agents but may still be used when other options are not suitable. Low blood sugar (hypoglycemia) is the most common side effect.

分子量

270.3500 g/mol

LogP

2.30

TPSA

83.70 Å²

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Cardiovascular Disease Pain Management Non-Small Cell Lung Cancer Psoriasis Lymphoma Type 2 Diabetes Breast Cancer Chronic Pain Hepatitis C Tuberculosis Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1

InChI

InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

Molecular Formula

C12H18N2O3S

HBD / HBA

2 / 3

可旋转键数

5

重原子数

18

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

This oral sulfonylurea medication stimulates the pancreas to produce more insulin and is used to lower blood sugar in adults with type 2 diabetes. It is an older drug largely replaced by newer agents but may still be used when other options are not suitable. Low blood sugar (hypoglycemia) is the most common side effect.

Yes, Tolbutamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL782. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5505. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C12H18N2O3S

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.