Vericiguat
Vericiguat is an oral soluble guanylate cyclase (sGC) stimulator that directly activates sGC independent of nitric oxide (NO) availability and sensitizes sGC to low levels of NO, increasing cyclic GMP (cGMP) production in vascular smooth muscle and cardiomyocytes. It is approved for reducing the risk of cardiovascular death and heart failure hospitalization in adults with symptomatic chronic heart failure with reduced ejection fraction (HFrEF) following a worsening heart failure event. Increased cGMP mediates vasodilation, reduced cardiac afterload, and cardioprotective signaling.
分子量
426.4000 g/mol
LogP
1.50
TPSA
147.00 Ų
Lipinski 五规则
符合
治疗领域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
COC(=O)Nc1c(N)nc(-c2nn(Cc3ccccc3F)c3ncc(F)cc23)nc1N
InChI
InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)
Molecular Formula
C19H16F2N8O2
HBD / HBA
3 / 10
可旋转键数
5
重原子数
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Vericiguat is an oral soluble guanylate cyclase (sGC) stimulator that directly activates sGC independent of nitric oxide (NO) availability and sensitizes sGC to low levels of NO, increasing cyclic GMP (cGMP) production in vascular smooth muscle and cardiomyocytes. It is approved for reducing the risk of cardiovascular death and heart failure hospitalization in adults with symptomatic chronic heart failure with reduced ejection fraction (HFrEF) following a worsening heart failure event. Increased cGMP mediates vasodilation, reduced cardiac afterload, and cardioprotective signaling.
Yes, Vericiguat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4066936. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 54674461. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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