Angiotensin-Converting Enzyme (ACE)
ACEA zinc metallopeptidase that converts angiotensin I to the potent vasoconstrictor angiotensin II and also degrades bradykinin. ACE inhibitors lower blood pressure by reducing angiotensin II formation and potentiating bradykinin-mediated vasodilation. The bradykinin accumulation also accounts for the characteristic dry cough side effect.
示例
- Enalapril — first orally active ACE inhibitor (prodrug of enalaprilat)
- Lisinopril — ACE inhibitor not requiring hepatic activation
- Ramipril — shown to reduce cardiovascular events in HOPE trial
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A zinc metallopeptidase that converts angiotensin I to the potent vasoconstrictor angiotensin II and also degrades bradykinin. ACE inhibitors lower blood pressure by reducing angiotensin II formation and potentiating bradykinin-mediated …