Cyclooxygenase (COX)
COXAn enzyme (COX-1 constitutive, COX-2 inducible) that catalyzes the conversion of arachidonic acid to prostaglandin H2, the precursor of prostaglandins and thromboxanes. COX-1 maintains gastric mucosal integrity and platelet function, while COX-2 mediates inflammation and pain. Selective COX-2 inhibition reduces GI toxicity but may increase cardiovascular risk.
示例
- Aspirin — irreversible COX-1/COX-2 inhibitor (antiplatelet, analgesic)
- Celecoxib — selective COX-2 inhibitor (arthritis)
- Ibuprofen — nonselective COX inhibitor (pain, inflammation)
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An enzyme (COX-1 constitutive, COX-2 inducible) that catalyzes the conversion of arachidonic acid to prostaglandin H2, the precursor of prostaglandins and thromboxanes. COX-1 maintains gastric mucosal integrity and platelet function, …