Drug-Induced Liver Injury (DILI)
DILIHepatotoxicity caused by medications, herbs, or supplements. The most common cause of acute liver failure in the US. Classified as hepatocellular, cholestatic, or mixed based on ALT/ALP ratio (R-value).
示例
- Acetaminophen (dose-dependent)
- Isoniazid (idiosyncratic)
- Hy's Law: ALT >3x + bilirubin >2x
您知道吗？
Hepatotoxicity caused by medications, herbs, or supplements. The most common cause of acute liver failure in the US. Classified as hepatocellular, cholestatic, or mixed based on ALT/ALP ratio (R-value).