Maximum Tolerated Dose (MTD)
MTDThe highest dose of a drug that does not cause unacceptable toxicity. Determined in dose-escalation Phase I studies. Critical for oncology drugs where efficacy often correlates with dose intensity.
示例
- 3+3 dose escalation design
- Dose-limiting toxicity (DLT)
- MTD-based dosing in oncology
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The highest dose of a drug that does not cause unacceptable toxicity. Determined in dose-escalation Phase I studies. Critical for oncology drugs where efficacy often correlates with dose intensity.