Major
Probable
描述
Hydroxychloroquine and ondansetron both prolong cardiac repolarization via hERG blockade; concurrent use substantially elevates arrhythmia risk.
机制
Additive IKr (hERG) blockade prolongs QTc in a dose-dependent manner; hydroxychloroquine may also affect sodium and calcium currents.
临床意义
Both drugs carry independent QT prolongation warnings; combination has been linked to torsades de pointes in case reports.
处理措施
Avoid concurrent use; if antiemesis is needed during hydroxychloroquine therapy, choose a non-QT-prolonging agent such as metoclopramide (with its own caveats) or a corticosteroid-based antiemetic strategy.