Major
Established
الوصف
Diazepam and zolpidem together produce compounded GABA-A-mediated CNS depression, with risk of severe sedation and respiratory compromise.
الآلية
Additive enhancement of GABA-A inhibitory neurotransmission; diazepam has longer duration of action which prolongs the interaction window.
الأهمية السريرية
Excess sedation, anterograde amnesia, and impaired psychomotor function are reliably increased with dual GABA-A modulator use.
التدبير
Avoid combination; if a hypnotic is needed during benzodiazepine therapy, optimize the benzodiazepine regimen first.