Buspirone
A non-benzodiazepine anxiolytic used for the long-term management of generalized anxiety disorder. It acts as a partial agonist at serotonin 5-HT1A receptors and has effects on dopamine receptors, without causing sedation or physical dependence. It takes several weeks to reach full therapeutic effect.
Molekularmasse
385,5000 g/mol
LogP
2,60
TPSA
69,60 Ų
Lipinski-Regel der Fünf
Bestanden
Therapeutische Bereiche
Wirkmechanismus
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …
2D-Struktur
Cite this structure
Embed this structure
SMILES
O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1
InChI
InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
Molecular Formula
C21H31N5O2
HBD / HBA
- / 6
Rotierbare Bindungen
6
Schwere Atome
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Häufig gestellte Fragen
A non-benzodiazepine anxiolytic used for the long-term management of generalized anxiety disorder. It acts as a partial agonist at serotonin 5-HT1A receptors and has effects on dopamine receptors, without causing sedation or physical dependence. It takes several weeks to reach full therapeutic effect.
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Yes, Buspirone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL49. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2477. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Medizinischer Haftungsausschluss
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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