Buspirone
A non-benzodiazepine anxiolytic used for the long-term management of generalized anxiety disorder. It acts as a partial agonist at serotonin 5-HT1A receptors and has effects on dopamine receptors, without causing sedation or physical dependence. It takes several weeks to reach full therapeutic effect.
分子量
385.5000 g/mol
LogP
2.60
TPSA
69.60 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …
二维结构
Cite this structure
Embed this structure
SMILES
O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1
InChI
InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
Molecular Formula
C21H31N5O2
HBD / HBA
- / 6
可旋转键数
6
重原子数
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A non-benzodiazepine anxiolytic used for the long-term management of generalized anxiety disorder. It acts as a partial agonist at serotonin 5-HT1A receptors and has effects on dopamine receptors, without causing sedation or physical dependence. It takes several weeks to reach full therapeutic effect.
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Yes, Buspirone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL49. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2477. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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