Lumacaftor

CHEMBL2103870 Phase 4 Zugelassen Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

452.4 g/mol

LogP

4.4

Phase

4

A CFTR corrector used in combination with ivacaftor to treat cystic fibrosis in patients with two copies of the F508del mutation. It helps the misfolded CFTR protein achieve a more stable configuration so it can reach the cell surface.

Molekularmasse

452,4000 g/mol

LogP

4,40

TPSA

97,80 Å²

Lipinski-Regel der Fünf

Bestanden

Therapeutische Bereiche

Type 2 Diabetes

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D-Struktur

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SMILES

Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1-c1cccc(C(=O)O)c1

InChI

InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)

Molecular Formula

C24H18F2N2O5

HBD / HBA

2 / 8

Rotierbare Bindungen

5

Schwere Atome

33

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Häufig gestellte Fragen

A CFTR corrector used in combination with ivacaftor to treat cystic fibrosis in patients with two copies of the F508del mutation. It helps the misfolded CFTR protein achieve a more stable configuration so it can reach the cell surface.

Yes, Lumacaftor is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2103870. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 16678941. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Struktur

Schnelldaten

Formel: C24H18F2N2O5
Synonyme: 1

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Medizinischer Haftungsausschluss

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.