Lumacaftor

CHEMBL2103870 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

452.4 g/mol

LogP

4.4

Phase

4

A CFTR corrector used in combination with ivacaftor to treat cystic fibrosis in patients with two copies of the F508del mutation. It helps the misfolded CFTR protein achieve a more stable configuration so it can reach the cell surface.

Masse moléculaire

452,4000 g/mol

LogP

4,40

TPSA

97,80 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Type 2 Diabetes

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1-c1cccc(C(=O)O)c1

InChI

InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)

Molecular Formula

C24H18F2N2O5

HBD / HBA

2 / 8

Liaisons Rotatives

5

Atomes Lourds

33

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

A CFTR corrector used in combination with ivacaftor to treat cystic fibrosis in patients with two copies of the F508del mutation. It helps the misfolded CFTR protein achieve a more stable configuration so it can reach the cell surface.

Yes, Lumacaftor is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2103870. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 16678941. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C24H18F2N2O5
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.