3,3',4',5-Tetrachlorosalicylanilide
An antimicrobial compound that was historically used in antiseptic soaps and skin preparations to kill bacteria and fungi on the skin's surface. It fell out of widespread use after concerns arose about skin sensitization and photosensitivity reactions in some individuals. Today it is rarely encountered in modern medical or consumer products.
Molecular Weight
351.0000 g/mol
LogP
5.90
TPSA
49.30 Ų
Lipinski RO5
Pass
Mechanism of Action
Disrupts microbial cell membranes and denatures proteins on contact, producing rapid broad-spectrum antimicrobial activity on skin and wound surfaces.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts microbial cell membranes and denatures proteins on contact, producing rapid broad-spectrum antimicrobial activity on skin and wound surfaces.
2D Structure
Cite this structure
Embed this structure
SMILES
O=C(Nc1ccc(Cl)c(Cl)c1)c1cc(Cl)cc(Cl)c1O
InChI
InChI=1S/C13H7Cl4NO2/c14-6-3-8(12(19)11(17)4-6)13(20)18-7-1-2-9(15)10(16)5-7/h1-5,19H,(H,18,20)
Molecular Formula
C13H7Cl4NO2
HBD / HBA
2 / 2
Rotatable Bonds
2
Heavy Atoms
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
An antimicrobial compound that was historically used in antiseptic soaps and skin preparations to kill bacteria and fungi on the skin's surface. It fell out of widespread use after concerns arose about skin sensitization and photosensitivity reactions in some individuals. Today it is rarely encountered in modern medical or consumer products.
Disrupts microbial cell membranes and denatures proteins on contact, producing rapid broad-spectrum antimicrobial activity on skin and wound surfaces.
Yes, 3,3',4',5-Tetrachlorosalicylanilide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL291338. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 14385. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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