Ciclesonide
A corticosteroid prodrug that is activated by airway esterases to its active metabolite des-ciclesonide, used as an inhaled therapy for persistent asthma and allergic rhinitis. Its prodrug design limits systemic absorption and local oropharyngeal side effects compared to some other inhaled corticosteroids. It provides effective anti-inflammatory control of airway disease with once-daily dosing.
Molecular Weight
540.7000 g/mol
LogP
5.30
TPSA
99.10 Ų
Lipinski RO5
Fail
Therapeutic Areas
Mechanism of Action
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
2D Structure
Cite this structure
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SMILES
CC(C)C(=O)OCC(=O)[C@@]12O[C@H](C3CCCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]12C
InChI
InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1
Molecular Formula
C32H44O7
HBD / HBA
1 / 7
Rotatable Bonds
6
Heavy Atoms
39
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A corticosteroid prodrug that is activated by airway esterases to its active metabolite des-ciclesonide, used as an inhaled therapy for persistent asthma and allergic rhinitis. Its prodrug design limits systemic absorption and local oropharyngeal side effects compared to some other inhaled corticosteroids. It provides effective anti-inflammatory control of airway disease with once-daily dosing.
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Yes, Ciclesonide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2040682. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6918155. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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