Dexrazoxane
A cardioprotective agent and bisdioxopiperazine prodrug that is hydrolyzed to an EDTA-like compound that chelates intracellular iron, reducing anthracycline-induced cardiac toxicity in cancer patients receiving high cumulative doxorubicin doses. It is also used to treat extravasation injury from anthracycline chemotherapy.
Molecular Weight
268.2700 g/mol
LogP
-1.40
TPSA
98.80 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
2D Structure
Cite this structure
Embed this structure
SMILES
C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1
InChI
InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
Molecular Formula
C11H16N4O4
HBD / HBA
2 / 6
Rotatable Bonds
3
Heavy Atoms
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A cardioprotective agent and bisdioxopiperazine prodrug that is hydrolyzed to an EDTA-like compound that chelates intracellular iron, reducing anthracycline-induced cardiac toxicity in cancer patients receiving high cumulative doxorubicin doses. It is also used to treat extravasation injury from anthracycline chemotherapy.
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Yes, Dexrazoxane is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1738. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 71384. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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