Erdafitinib

CHEMBL3545376 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

446.5 g/mol

LogP

3.2

Phase

4

This oral medication blocks FGFR enzymes that are mutated or overactive in certain cancers, slowing tumor cell growth and division. It is approved for the treatment of FGFR-altered urothelial carcinoma.

Molecular Weight

446.5000 g/mol

LogP

3.20

TPSA

77.30 Å²

Lipinski RO5

Pass

Therapeutic Areas

Bladder Cancer Breast Cancer Colorectal Cancer Lymphoma Melanoma Non-Small Cell Lung Cancer Ovarian Cancer Pancreatic Cancer Prostate Cancer Thyroid Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1

InChI

InChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3

Molecular Formula

C25H30N6O2

HBD / HBA

1 / 7

Rotatable Bonds

9

Heavy Atoms

33

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

This oral medication blocks FGFR enzymes that are mutated or overactive in certain cancers, slowing tumor cell growth and division. It is approved for the treatment of FGFR-altered urothelial carcinoma.

Yes, Erdafitinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3545376. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 67462786. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C25H30N6O2
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.