Levoketoconazole
This medication is used to treat Cushing's syndrome, a condition caused by excess cortisol in the body, by blocking the enzymes that produce cortisol in the adrenal glands. It is the active enantiomer of ketoconazole, designed specifically to lower cortisol levels while reducing some of the side effects associated with the parent compound.
Molecular Weight
531.4000 g/mol
LogP
4.30
TPSA
69.10 Ų
Lipinski RO5
Pass
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
CC(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1
InChI
InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
Molecular Formula
C26H28Cl2N4O4
HBD / HBA
- / 6
Rotatable Bonds
7
Heavy Atoms
36
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
This medication is used to treat Cushing's syndrome, a condition caused by excess cortisol in the body, by blocking the enzymes that produce cortisol in the adrenal glands. It is the active enantiomer of ketoconazole, designed specifically to lower cortisol levels while reducing some of the side effects associated with the parent compound.
Yes, Levoketoconazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL295698. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 47576. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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