Lomitapide

CHEMBL354541 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

693.7 g/mol

LogP

8.6

Phase

4

A microsomal triglyceride transfer protein (MTP) inhibitor used to treat homozygous familial hypercholesterolemia, a rare genetic disorder causing extremely high cholesterol. It reduces LDL cholesterol by blocking the assembly of lipoproteins in the liver.

Molecular Weight

693.7000 g/mol

LogP

8.60

TPSA

61.40 Å²

Lipinski RO5

Fail

Therapeutic Areas

Hyperlipidemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

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SMILES

O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1

InChI

InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)

Molecular Formula

C39H37F6N3O2

HBD / HBA

2 / 9

Rotatable Bonds

10

Heavy Atoms

50

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

A microsomal triglyceride transfer protein (MTP) inhibitor used to treat homozygous familial hypercholesterolemia, a rare genetic disorder causing extremely high cholesterol. It reduces LDL cholesterol by blocking the assembly of lipoproteins in the liver.

Yes, Lomitapide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL354541. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 9853053. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Quick Data

Formula: C39H37F6N3O2
Synonyms: 1

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.