Masoprocol
This compound derived from the creosote bush plant was approved as a topical treatment for a precancerous skin condition called actinic keratosis, working by inhibiting an enzyme involved in the production of inflammatory compounds that promote abnormal cell growth. It was withdrawn due to a high rate of allergic contact dermatitis.
Molecular Weight
302.4000 g/mol
LogP
4.30
TPSA
80.90 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
2D Structure
Cite this structure
Embed this structure
SMILES
C[C@H](Cc1ccc(O)c(O)c1)[C@@H](C)Cc1ccc(O)c(O)c1
InChI
InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
Molecular Formula
C18H22O4
HBD / HBA
4 / 4
Rotatable Bonds
5
Heavy Atoms
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
This compound derived from the creosote bush plant was approved as a topical treatment for a precancerous skin condition called actinic keratosis, working by inhibiting an enzyme involved in the production of inflammatory compounds that promote abnormal cell growth. It was withdrawn due to a high rate of allergic contact dermatitis.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Masoprocol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL313972. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 71398. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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