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Pemigatinib

CHEMBL4297522 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
487.5 g/mol
LogP
1.8
Phase
4

This targeted therapy treats cancers with FGFR gene changes by blocking the abnormal protein driving cancer growth.

Molecular Weight

487.5000 g/mol

LogP

1.80

TPSA

83.20 Ų

Lipinski RO5

Pass

Therapeutic Areas

Bladder Cancer Breast Cancer Chronic Obstructive Pulmonary Disease Colorectal Cancer Glaucoma Leukemia Lymphoma Non-Small Cell Lung Cancer Ovarian Cancer Pancreatic Cancer Prostate Cancer Thyroid Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

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SMILES

                    
CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc3[nH]c(CN4CCOCC4)cc3c21

                

                

                
                

                    
InChI

                    
InChI=1S/C24H27F2N5O4/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26/h9-11H,4-8,12-13H2,1-3H3,(H,27,28)

                

                

                

                    
                    

                        
Molecular Formula

                        
C24H27F2N5O4

                    

                    
                    

                        
HBD / HBA

                        
1 / 8

                    

                    
                    

                        
Rotatable Bonds

                        
6

                    

                    
                    
                    

                        
Heavy Atoms

                        
35

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
This targeted therapy treats cancers with FGFR gene changes by blocking the abnormal protein driving cancer growth.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Pemigatinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL4297522.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 86705695.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.