Practolol

CHEMBL6995 Phase 4 Approved Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

266.3 g/mol

LogP

0.8

Phase

4

Practolol is a cardioselective beta-1 adrenergic receptor blocker that reduces heart rate, myocardial contractility, and blood pressure by competitively blocking catecholamine binding at cardiac beta-1 receptors. It was withdrawn from systemic use due to an oculomucocutaneous syndrome causing serious ocular, skin, and peritoneal fibrosis complications, though it retains use in some countries as an intravenous agent for intraoperative arrhythmia management.

Molecular Weight

266.3400 g/mol

LogP

0.80

TPSA

70.60 Å²

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

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SMILES

CC(=O)Nc1ccc(OCC(O)CNC(C)C)cc1

InChI

InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)

Molecular Formula

C14H22N2O3

HBD / HBA

3 / 4

Rotatable Bonds

7

Heavy Atoms

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Frequently Asked Questions

Practolol is a cardioselective beta-1 adrenergic receptor blocker that reduces heart rate, myocardial contractility, and blood pressure by competitively blocking catecholamine binding at cardiac beta-1 receptors. It was withdrawn from systemic use due to an oculomucocutaneous syndrome causing serious ocular, skin, and peritoneal fibrosis complications, though it retains use in some countries as an intravenous agent for intraoperative arrhythmia management.

Yes, Practolol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL6995. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 4883. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Quick Data

Formula: C14H22N2O3

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Medical Disclaimer

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.