Pregabalin
Used to relieve nerve pain caused by conditions such as diabetic neuropathy, shingles, fibromyalgia, and spinal cord injury, and also used as an add-on treatment to control certain types of seizures in epilepsy. It works by reducing abnormal electrical activity in the nervous system that causes pain and seizures.
Molecular Weight
159.2260 g/mol
LogP
-1.60
TPSA
63.30 Ų
Lipinski RO5
Pass
Therapeutic Areas
Drug Classes
Mechanism of Action
Binds alpha-2-delta subunit of voltage-gated calcium channels.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds alpha-2-delta subunit of voltage-gated calcium channels.
2D Structure
Cite this structure
Embed this structure
SMILES
CC(C)C[C@H](CN)CC(=O)O
InChI
InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
Molecular Formula
C8H17NO2
HBD / HBA
2 / 3
Rotatable Bonds
5
Heavy Atoms
11
Pregabalin potentiates the respiratory depressant and sedative effects of morphine, creating a high-risk combination for overdose.
Pregabalin combined with oxycodone produces synergistic respiratory and CNS depression, substantially elevating overdose risk.
Duloxetine and pregabalin are commonly co-prescribed for neuropathic pain with complementary mechanisms; additive CNS effects including dizziness, somnolence, and cognitive impairment can occur.
Omeprazole does not have a pharmacokinetic interaction with pregabalin since pregabalin is not CYP-metabolised; however, both can cause peripheral oedema through independent mechanisms, producing additive fluid retention.
Combining gabapentin and pregabalin, two alpha-2-delta ligands with similar mechanisms, produces additive CNS depression and dose-dependent adverse effects including respiratory depression, dizziness, and somnolence.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Used to relieve nerve pain caused by conditions such as diabetic neuropathy, shingles, fibromyalgia, and spinal cord injury, and also used as an add-on treatment to control certain types of seizures in epilepsy. It works by reducing abnormal electrical activity in the nervous system that causes pain and seizures.
Binds alpha-2-delta subunit of voltage-gated calcium channels.
Key pharmacokinetic parameters for Pregabalin: Half-life: 6.3 hours.
Yes, Pregabalin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1059. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5486971. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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