Minor
Suspected
Description
Omeprazole does not have a pharmacokinetic interaction with pregabalin since pregabalin is not CYP-metabolised; however, both can cause peripheral oedema through independent mechanisms, producing additive fluid retention.
Mechanism
Pregabalin causes peripheral oedema through an unclear mechanism, possibly related to calcium channel-mediated vascular tone changes; omeprazole rarely causes fluid retention; the combination is predominantly pharmacodynamic.
Clinical Significance
The interaction is minor and clinically relevant only in patients prone to fluid retention (e.g., cardiac failure, hypoalbuminaemia).
Management
Monitor for peripheral oedema; no dose adjustment required; consider reviewing pregabalin dose if oedema worsens.