Stiripentol
Stiripentol is a structurally unique antiepileptic agent that acts through multiple mechanisms including potentiation of GABA-A receptor function, inhibition of voltage-dependent sodium channels, and inhibition of cytochrome P450 enzymes (CYP2C19 and CYP3A4), used for the adjunctive treatment of seizures in Dravet syndrome (severe myoclonic epilepsy of infancy) in patients also receiving clobazam and valproate. By inhibiting the metabolism of clobazam to its active metabolite norclobazam, and by directly potentiating GABAergic inhibition, it provides synergistic anticonvulsant effects. It is an orphan drug specifically indicated for this pharmacogenomically defined syndrome.
Molecular Weight
234.2900 g/mol
LogP
3.60
TPSA
38.70 Ų
Lipinski RO5
Pass
Therapeutic Areas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Structure
Cite this structure
Embed this structure
SMILES
CC(C)(C)C(O)/C=C/c1ccc2c(c1)OCO2
InChI
InChI=1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+
Molecular Formula
C14H18O3
HBD / HBA
1 / 3
Rotatable Bonds
3
Heavy Atoms
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Stiripentol is a structurally unique antiepileptic agent that acts through multiple mechanisms including potentiation of GABA-A receptor function, inhibition of voltage-dependent sodium channels, and inhibition of cytochrome P450 enzymes (CYP2C19 and CYP3A4), used for the adjunctive treatment of seizures in Dravet syndrome (severe myoclonic epilepsy of infancy) in patients also receiving clobazam and valproate. By inhibiting the metabolism of clobazam to its active metabolite norclobazam, and by directly potentiating GABAergic inhibition, it provides synergistic anticonvulsant effects. It is an orphan …
Yes, Stiripentol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1983350. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5311454. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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