Sulfadiazine, Silver
Silver sulfadiazine is a topical antimicrobial compound combining silver ions and sulfadiazine that acts through dual mechanisms: silver ions denature bacterial DNA and disrupt bacterial cell membranes, while sulfadiazine inhibits dihydropteroate synthase to block folate synthesis, providing broad-spectrum activity including Pseudomonas aeruginosa. It is used extensively for prevention and treatment of wound infection in partial and full-thickness burn injuries. The sustained release of silver ions from the cream provides prolonged antimicrobial activity at the wound surface.
Molecular Weight
357.1400 g/mol
TPSA
95.30 Ų
Mechanism of Action
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
2D Structure
Cite this structure
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SMILES
Nc1ccc(S(=O)(=O)[N-]c2ncccn2)cc1.[Ag+]
InChI
InChI=1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
Molecular Formula
C10H9AgN4O2S
HBD / HBA
1 / 6
Rotatable Bonds
3
Heavy Atoms
18
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Silver sulfadiazine is a topical antimicrobial compound combining silver ions and sulfadiazine that acts through dual mechanisms: silver ions denature bacterial DNA and disrupt bacterial cell membranes, while sulfadiazine inhibits dihydropteroate synthase to block folate synthesis, providing broad-spectrum activity including Pseudomonas aeruginosa. It is used extensively for prevention and treatment of wound infection in partial and full-thickness burn injuries. The sustained release of silver ions from the cream provides prolonged antimicrobial activity at the wound surface.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Sulfadiazine, Silver is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1382627. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 441244. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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