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Tocopherol Acetate

CHEMBL3989859 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
472.7 g/mol
LogP
10.8
Phase
4

Tocopherol acetate (vitamin E acetate) is the esterified, more stable form of alpha-tocopherol that is hydrolyzed in vivo to the active antioxidant vitamin E, which protects cell membranes from oxidative damage by neutralizing lipid peroxy radicals as a chain-breaking antioxidant. It is used as a nutritional supplement for vitamin E deficiency and is included in multivitamin preparations, and has been investigated for prevention of age-related macular degeneration and Alzheimer's disease through antioxidant mechanisms. Its ester form provides greater stability against oxidation during storage compared to free tocopherol.

Molecular Weight

472.7000 g/mol

LogP

10.80

TPSA

35.50 Ų

Lipinski RO5

Pass

Therapeutic Areas

Age-Related Macular Degeneration Alzheimer's Disease Asthma Bipolar Disorder Bladder Cancer Breast Cancer Cardiovascular Disease Chronic Kidney Disease Chronic Obstructive Pulmonary Disease Chronic Pain Colorectal Cancer Dermatology Epilepsy Generalized Anxiety Disorder Glaucoma Hepatitis C Hypertension Malaria Migraine Multiple Sclerosis Non-Alcoholic Fatty Liver Disease Non-Small Cell Lung Cancer Obesity Ovarian Cancer Pain Management Pancreatic Cancer Prostate Cancer Rheumatoid Arthritis Schizophrenia Stroke Thyroid Cancer Type 2 Diabetes

Mechanism of Action

Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mechanism

Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)Oc1c(C)c(C)c2c(c1C)CCC(C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O2

                

                

                
                

                    
InChI

                    
InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31?/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C31H52O3

                    

                    
                    

                        
HBD / HBA

                        
- / 3

                    

                    
                    

                        
Rotatable Bonds

                        
14

                    

                    
                    
                    

                        
Heavy Atoms

                        
34

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
Tocopherol acetate (vitamin E acetate) is the esterified, more stable form of alpha-tocopherol that is hydrolyzed in vivo to the active antioxidant vitamin E, which protects cell membranes from oxidative damage by neutralizing lipid peroxy radicals as a chain-breaking antioxidant. It is used as a nutritional supplement for vitamin E deficiency and is included in multivitamin preparations, and has been investigated for prevention of age-related macular degeneration and Alzheimer's disease through antioxidant mechanisms. Its ester form provides greater stability against …

                        

                    

                    

                    

                    
                    

                        
                        

                            
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tocopherol Acetate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3989859.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 86472.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.