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Tocopherol Acetate

CHEMBL3989859 Phase 4 Aprovado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
472.7 g/mol
LogP
10.8
Phase
4

Tocopherol acetate (vitamin E acetate) is the esterified, more stable form of alpha-tocopherol that is hydrolyzed in vivo to the active antioxidant vitamin E, which protects cell membranes from oxidative damage by neutralizing lipid peroxy radicals as a chain-breaking antioxidant. It is used as a nutritional supplement for vitamin E deficiency and is included in multivitamin preparations, and has been investigated for prevention of age-related macular degeneration and Alzheimer's disease through antioxidant mechanisms. Its ester form provides greater stability against oxidation during storage compared to free tocopherol.

Peso Molecular

472,7000 g/mol

LogP

10,80

TPSA

35,50 Ų

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Glaucoma Cardiovascular Disease Age-Related Macular Degeneration Dermatology Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Asthma Chronic Obstructive Pulmonary Disease Alzheimer's Disease Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Multiple Sclerosis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Stroke Obesity Type 2 Diabetes Hypertension Breast Cancer Chronic Pain Malaria Hepatitis C Prostate Cancer Colorectal Cancer

Mecanismo de Ação

Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.

Estrutura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)Oc1c(C)c(C)c2c(c1C)CCC(C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O2

                

                

                
                

                    
InChI

                    
InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31?/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C31H52O3

                    

                    
                    

                        
HBD / HBA

                        
- / 3

                    

                    
                    

                        
Ligações Rotacionáveis

                        
14

                    

                    
                    
                    

                        
Átomos Pesados

                        
34

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
Tocopherol acetate (vitamin E acetate) is the esterified, more stable form of alpha-tocopherol that is hydrolyzed in vivo to the active antioxidant vitamin E, which protects cell membranes from oxidative damage by neutralizing lipid peroxy radicals as a chain-breaking antioxidant. It is used as a nutritional supplement for vitamin E deficiency and is included in multivitamin preparations, and has been investigated for prevention of age-related macular degeneration and Alzheimer's disease through antioxidant mechanisms. Its ester form provides greater stability against …

                        

                    

                    

                    

                    
                    

                        
                        

                            
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tocopherol Acetate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3989859.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 86472.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.