Chloramphenicol
A broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, active against a wide range of gram-positive, gram-negative, and anaerobic bacteria. Its systemic use is restricted due to the risk of serious blood disorders, including aplastic anemia. Topical ophthalmic formulations remain widely used for eye infections.
Peso molecular
323,1300 g/mol
LogP
1,10
TPSA
115,00 Ų
Regla de cinco de Lipinski
Cumple
Mecanismo de acción
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Estructura 2D
Cite this structure
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SMILES
O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)C(Cl)Cl
InChI
InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
Molecular Formula
C11H12Cl2N2O5
HBD / HBA
3 / 5
Enlaces Rotables
5
Átomos Pesados
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, active against a wide range of gram-positive, gram-negative, and anaerobic bacteria. Its systemic use is restricted due to the risk of serious blood disorders, including aplastic anemia. Topical ophthalmic formulations remain widely used for eye infections.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Chloramphenicol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL130. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5959. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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