Dofetilide

CHEMBL473 Phase 4 Aprobado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

441.6 g/mol

LogP

1.8

Phase

4

A class III antiarrhythmic drug used to convert atrial fibrillation and flutter to normal sinus rhythm and to maintain normal rhythm after conversion. It works by blocking potassium channels in the heart, prolonging the action potential. It can cause a potentially dangerous prolongation of the QT interval leading to life-threatening arrhythmias, so initiation must occur in hospital with continuous cardiac monitoring.

Peso molecular

441,6000 g/mol

LogP

1,80

TPSA

122,00 Å²

Regla de cinco de Lipinski

Cumple

Áreas terapéuticas

Fibrilación auricular Ictus Insuficiencia cardíaca

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estructura 2D

SVG PNG

Cite this structure

Embed this structure

SMILES

CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1

InChI

InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3

Molecular Formula

C19H27N3O5S2

HBD / HBA

2 / 8

Enlaces Rotables

11

Átomos Pesados

29

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Preguntas frecuentes

A class III antiarrhythmic drug used to convert atrial fibrillation and flutter to normal sinus rhythm and to maintain normal rhythm after conversion. It works by blocking potassium channels in the heart, prolonging the action potential. It can cause a potentially dangerous prolongation of the QT interval leading to life-threatening arrhythmias, so initiation must occur in hospital with continuous cardiac monitoring.

Yes, Dofetilide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL473. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 71329. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

PillFYI

¿Busca información accesible para el paciente?

Dofetilide en PillFYI

Estructura

Datos Rápidos

Fórmula: C19H27N3O5S2
Sinónimos: 1

Enlaces externos

Cite

BibTeX, APA, MLA, Chicago, IEEE, Harvard

Aviso médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.