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Dofetilide

CHEMBL473 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
441.6 g/mol
LogP
1.8
Phase
4

A class III antiarrhythmic drug used to convert atrial fibrillation and flutter to normal sinus rhythm and to maintain normal rhythm after conversion. It works by blocking potassium channels in the heart, prolonging the action potential. It can cause a potentially dangerous prolongation of the QT interval leading to life-threatening arrhythmias, so initiation must occur in hospital with continuous cardiac monitoring.

Khối lượng phân tử

441,6000 g/mol

LogP

1,80

TPSA

122,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Stroke Heart Failure Atrial Fibrillation

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H27N3O5S2

                    

                    
                    

                        
HBD / HBA

                        
2 / 8

                    

                    
                    

                        
Liên kết có thể quay

                        
11

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A class III antiarrhythmic drug used to convert atrial fibrillation and flutter to normal sinus rhythm and to maintain normal rhythm after conversion. It works by blocking potassium channels in the heart, prolonging the action potential. It can cause a potentially dangerous prolongation of the QT interval leading to life-threatening arrhythmias, so initiation must occur in hospital with continuous cardiac monitoring.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Dofetilide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL473.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 71329.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.