Sibutramine
Sibutramine is a centrally acting serotonin-norepinephrine reuptake inhibitor originally developed as an antidepressant and later used as an anti-obesity agent for weight management. By inhibiting reuptake of serotonin, norepinephrine, and to a lesser extent dopamine, it promotes satiety and reduces food intake while modestly increasing energy expenditure. It was withdrawn from markets in many countries due to increased risk of major adverse cardiovascular events in high-risk patients.
Peso molecular
279,8000 g/mol
LogP
5,40
TPSA
3,20 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1
InChI
InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3
Molecular Formula
C17H26ClN
HBD / HBA
- / 1
Enlaces Rotables
5
Átomos Pesados
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Sibutramine is a centrally acting serotonin-norepinephrine reuptake inhibitor originally developed as an antidepressant and later used as an anti-obesity agent for weight management. By inhibiting reuptake of serotonin, norepinephrine, and to a lesser extent dopamine, it promotes satiety and reduces food intake while modestly increasing energy expenditure. It was withdrawn from markets in many countries due to increased risk of major adverse cardiovascular events in high-risk patients.
Yes, Sibutramine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1419. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5210. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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