Sodium Phenylacetate

CHEMBL1200358 Phase 4 Aprobado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

158.1 g/mol

LogP

—

Phase

4

Sodium phenylacetate is a nitrogen-scavenging agent used in combination with sodium benzoate for the emergency treatment of acute hyperammonemia in patients with urea cycle disorders. Phenylacetate conjugates with glutamine (via phenylacetylglutamine) in the liver and kidney, enabling renal excretion of excess nitrogen that cannot be eliminated via the defective urea cycle. The combination product (Ammonul) is administered intravenously for acute hyperammonemic crisis.

Peso molecular

158,1300 g/mol

TPSA

40,10 Å²

Áreas terapéuticas

Artritis reumatoide Cáncer de mama Cáncer de vejiga Dolor crónico Gota Manejo del dolor Migraña Trastorno de ansiedad generalizada

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estructura 2D

SVG PNG

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SMILES

O=C([O-])Cc1ccccc1.[Na+]

InChI

InChI=1S/C8H8O2.Na/c9-8(10)6-7-4-2-1-3-5-7;/h1-5H,6H2,(H,9,10);/q;+1/p-1

Molecular Formula

C8H7NaO2

HBD / HBA

- / 2

Enlaces Rotables

2

Átomos Pesados

11

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Preguntas frecuentes

Sodium phenylacetate is a nitrogen-scavenging agent used in combination with sodium benzoate for the emergency treatment of acute hyperammonemia in patients with urea cycle disorders. Phenylacetate conjugates with glutamine (via phenylacetylglutamine) in the liver and kidney, enabling renal excretion of excess nitrogen that cannot be eliminated via the defective urea cycle. The combination product (Ammonul) is administered intravenously for acute hyperammonemic crisis.

Yes, Sodium Phenylacetate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200358. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 23690424. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Estructura

Datos Rápidos

Fórmula: C8H7NaO2
Sinónimos: 1

Enlaces externos

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Aviso médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.