Stavudine
An older antiretroviral nucleoside analogue that was widely used in early HIV treatment regimens by blocking the reverse transcriptase enzyme the virus needs to replicate. It has largely been replaced by better-tolerated alternatives due to its risk of causing peripheral nerve damage and serious metabolic complications with long-term use.
Peso molecular
224,2100 g/mol
LogP
-0,80
TPSA
78,90 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.
Estructura 2D
Cite this structure
Embed this structure
SMILES
Cc1cn([C@H]2C=C[C@@H](CO)O2)c(=O)[nH]c1=O
InChI
InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1
Molecular Formula
C10H12N2O4
HBD / HBA
2 / 4
Enlaces Rotables
2
Átomos Pesados
16
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
An older antiretroviral nucleoside analogue that was widely used in early HIV treatment regimens by blocking the reverse transcriptase enzyme the virus needs to replicate. It has largely been replaced by better-tolerated alternatives due to its risk of causing peripheral nerve damage and serious metabolic complications with long-term use.
Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.
Yes, Stavudine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL991. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 18283. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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