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Stavudine

CHEMBL991 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
224.2 g/mol
LogP
-0.8
Phase
4

An older antiretroviral nucleoside analogue that was widely used in early HIV treatment regimens by blocking the reverse transcriptase enzyme the virus needs to replicate. It has largely been replaced by better-tolerated alternatives due to its risk of causing peripheral nerve damage and serious metabolic complications with long-term use.

分子量

224.2100 g/mol

LogP

-0.80

TPSA

78.90 Ų

Lipinski 五规则

符合

治疗领域

Cardiovascular Disease Malaria HIV/AIDS Hepatitis C Tuberculosis

作用机制

Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cc1cn([C@H]2C=C[C@@H](CO)O2)c(=O)[nH]c1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H12N2O4

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
可旋转键数

                        
2

                    

                    
                    
                    

                        
重原子数

                        
16

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
An older antiretroviral nucleoside analogue that was widely used in early HIV treatment regimens by blocking the reverse transcriptase enzyme the virus needs to replicate. It has largely been replaced by better-tolerated alternatives due to its risk of causing peripheral nerve damage and serious metabolic complications with long-term use.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Stavudine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL991.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 18283.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.