Sulconazole
Sulconazole is a broad-spectrum imidazole antifungal agent used topically for the treatment of dermatophyte infections including tinea pedis, tinea corporis, tinea cruris, and tinea versicolor. It inhibits fungal lanosterol 14-alpha demethylase, a cytochrome P450 enzyme essential for ergosterol biosynthesis, disrupting fungal cell membrane integrity and function. It also has some anti-gram-positive bacterial activity.
Peso molecular
397,7000 g/mol
LogP
6,10
TPSA
43,10 Ų
Regla de cinco de Lipinski
Cumple
Mecanismo de acción
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Estructura 2D
Cite this structure
Embed this structure
SMILES
Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1
InChI
InChI=1S/C18H15Cl3N2S/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
Molecular Formula
C18H15Cl3N2S
HBD / HBA
- / 2
Enlaces Rotables
6
Átomos Pesados
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Sulconazole is a broad-spectrum imidazole antifungal agent used topically for the treatment of dermatophyte infections including tinea pedis, tinea corporis, tinea cruris, and tinea versicolor. It inhibits fungal lanosterol 14-alpha demethylase, a cytochrome P450 enzyme essential for ergosterol biosynthesis, disrupting fungal cell membrane integrity and function. It also has some anti-gram-positive bacterial activity.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Sulconazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1221. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5318. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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