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Sulconazole

CHEMBL1221 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
397.7 g/mol
LogP
6.1
Phase
4

Sulconazole is a broad-spectrum imidazole antifungal agent used topically for the treatment of dermatophyte infections including tinea pedis, tinea corporis, tinea cruris, and tinea versicolor. It inhibits fungal lanosterol 14-alpha demethylase, a cytochrome P450 enzyme essential for ergosterol biosynthesis, disrupting fungal cell membrane integrity and function. It also has some anti-gram-positive bacterial activity.

Khối lượng phân tử

397,7000 g/mol

LogP

6,10

TPSA

43,10 Ų

Lipinski RO5

Đạt

Cơ chế tác dụng

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C18H15Cl3N2S/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H15Cl3N2S

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Liên kết có thể quay

                        
6

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
24

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Sulconazole is a broad-spectrum imidazole antifungal agent used topically for the treatment of dermatophyte infections including tinea pedis, tinea corporis, tinea cruris, and tinea versicolor. It inhibits fungal lanosterol 14-alpha demethylase, a cytochrome P450 enzyme essential for ergosterol biosynthesis, disrupting fungal cell membrane integrity and function. It also has some anti-gram-positive bacterial activity.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Sulconazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1221.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5318.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.