Thonzonium
Thonzonium is a quaternary ammonium compound with surfactant and antimicrobial properties that acts as a penetration enhancer by reducing surface tension and disrupting microbial membranes, facilitating penetration of co-administered antimicrobial agents into ear canal tissues. It is used as an excipient/adjuvant in otic combination preparations containing corticosteroids and antibiotics for otitis externa. Its ability to disperse coagulated or necrotic debris in the ear canal enhances drug contact with infected tissue.
Peso molecular
511,8000 g/mol
LogP
9,90
TPSA
38,30 Ų
Regla de cinco de Lipinski
No cumple
Mecanismo de acción
Reduces surface tension at the air-liquid interface in the pulmonary alveoli, preventing alveolar collapse during expiration and improving lung compliance and gas exchange.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Reduces surface tension at the air-liquid interface in the pulmonary alveoli, preventing alveolar collapse during expiration and improving lung compliance and gas exchange.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CCCCCCCCCCCCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c1ncccn1
InChI
InChI=1S/C32H55N4O/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27-36(2,3)28-26-35(32-33-24-19-25-34-32)29-30-20-22-31(37-4)23-21-30/h19-25H,5-18,26-29H2,1-4H3/q+1
Molecular Formula
C32H55N4O+
HBD / HBA
- / 4
Enlaces Rotables
22
Átomos Pesados
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Thonzonium is a quaternary ammonium compound with surfactant and antimicrobial properties that acts as a penetration enhancer by reducing surface tension and disrupting microbial membranes, facilitating penetration of co-administered antimicrobial agents into ear canal tissues. It is used as an excipient/adjuvant in otic combination preparations containing corticosteroids and antibiotics for otitis externa. Its ability to disperse coagulated or necrotic debris in the ear canal enhances drug contact with infected tissue.
Reduces surface tension at the air-liquid interface in the pulmonary alveoli, preventing alveolar collapse during expiration and improving lung compliance and gas exchange.
Yes, Thonzonium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201322. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5456. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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