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Thonzonium

CHEMBL1201322 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
511.8 g/mol
LogP
9.9
Phase
4

Thonzonium is a quaternary ammonium compound with surfactant and antimicrobial properties that acts as a penetration enhancer by reducing surface tension and disrupting microbial membranes, facilitating penetration of co-administered antimicrobial agents into ear canal tissues. It is used as an excipient/adjuvant in otic combination preparations containing corticosteroids and antibiotics for otitis externa. Its ability to disperse coagulated or necrotic debris in the ear canal enhances drug contact with infected tissue.

น้ำหนักโมเลกุล

511.8000 g/mol

LogP

9.90

TPSA

38.30 Ų

Lipinski RO5

ไม่ผ่าน

กลไกการออกฤทธิ์

Reduces surface tension at the air-liquid interface in the pulmonary alveoli, preventing alveolar collapse during expiration and improving lung compliance and gas exchange.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Reduces surface tension at the air-liquid interface in the pulmonary alveoli, preventing alveolar collapse during expiration and improving lung compliance and gas exchange.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCCCCCCCCCCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c1ncccn1

                

                

                
                

                    
InChI

                    
InChI=1S/C32H55N4O/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27-36(2,3)28-26-35(32-33-24-19-25-34-32)29-30-20-22-31(37-4)23-21-30/h19-25H,5-18,26-29H2,1-4H3/q+1

                

                

                

                    
                    

                        
Molecular Formula

                        
C32H55N4O+

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
พันธะที่หมุนได้

                        
22

                    

                    
                    
                    

                        
อะตอมหนัก

                        
37

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Thonzonium is a quaternary ammonium compound with surfactant and antimicrobial properties that acts as a penetration enhancer by reducing surface tension and disrupting microbial membranes, facilitating penetration of co-administered antimicrobial agents into ear canal tissues. It is used as an excipient/adjuvant in otic combination preparations containing corticosteroids and antibiotics for otitis externa. Its ability to disperse coagulated or necrotic debris in the ear canal enhances drug contact with infected tissue.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Reduces surface tension at the air-liquid interface in the pulmonary alveoli, preventing alveolar collapse during expiration and improving lung compliance and gas exchange.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Thonzonium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201322.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5456.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.