Axitinib

CHEMBL1289926 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

386.5 g/mol

LogP

4.2

Phase

4

A potent inhibitor of vascular endothelial growth factor receptors that cuts off the blood supply that tumors need to grow, used for renal cell carcinoma. It is taken by mouth and can cause high blood pressure as a common side effect.

Masse moléculaire

386,5000 g/mol

LogP

4,20

TPSA

96,00 Å²

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Age-Related Macular Degeneration Non-Small Cell Lung Cancer Melanoma Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

SVG PNG

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SMILES

CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1

InChI

InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

Molecular Formula

C22H18N4OS

HBD / HBA

2 / 4

Liaisons Rotatives

5

Atomes Lourds

28

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

A potent inhibitor of vascular endothelial growth factor receptors that cuts off the blood supply that tumors need to grow, used for renal cell carcinoma. It is taken by mouth and can cause high blood pressure as a common side effect.

Yes, Axitinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1289926. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6450551. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Structure

Données Clés

Formule: C22H18N4OS
Synonymes: 1

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.