Indomethacin
This potent nonsteroidal anti-inflammatory drug (NSAID) is used to treat moderate-to-severe pain and inflammation in conditions such as arthritis, gout, bursitis, and tendinitis. It works by inhibiting cyclooxygenase (COX) enzymes that produce prostaglandins. In newborns, intravenous indomethacin is used to close a patent ductus arteriosus.
Masse moléculaire
357,8000 g/mol
LogP
4,30
TPSA
68,50 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Structure 2D
Cite this structure
Embed this structure
SMILES
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1
InChI
InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
Molecular Formula
C19H16ClNO4
HBD / HBA
1 / 4
Liaisons Rotatives
4
Atomes Lourds
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
This potent nonsteroidal anti-inflammatory drug (NSAID) is used to treat moderate-to-severe pain and inflammation in conditions such as arthritis, gout, bursitis, and tendinitis. It works by inhibiting cyclooxygenase (COX) enzymes that produce prostaglandins. In newborns, intravenous indomethacin is used to close a patent ductus arteriosus.
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Yes, Indomethacin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL6. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3715. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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