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Levofloxacin

CHEMBL5315124 Phase 4 Approuvé Small molecule
Half-Life
6-8 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
361.4 g/mol
LogP
-0.4
Phase
4

A broad-spectrum fluoroquinolone antibiotic used to treat respiratory tract infections, urinary tract infections, skin infections, and certain cases of anthrax. It works by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes.

Masse moléculaire

361,3680 g/mol

LogP

-0,40

TPSA

73,30 Ų

Règle des 5 de Lipinski

Conforme

Aires thérapeutiques

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Benign Prostatic Hyperplasia Glaucoma Age-Related Macular Degeneration Non-Small Cell Lung Cancer Chronic Obstructive Pulmonary Disease Infectious Disease Stroke Obesity Lymphoma Hypertension Breast Cancer Malaria HIV/AIDS Tuberculosis Heart Failure Prostate Cancer Colorectal Cancer Leukemia

Classes de médicaments

J — J - Antiinfectives for Systemic Use

Mécanisme d'action

Fluoroquinolone antibiotic inhibiting bacterial DNA gyrase and topoisomerase IV.

Pharmacokinetics (PK)

Half-Life 6-8 hours

Pharmacodynamics (PD)

Mécanisme

Fluoroquinolone antibiotic inhibiting bacterial DNA gyrase and topoisomerase IV.

Structure 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.O

                

                

                
                

                    
InChI

                    
InChI=1S/2C18H20FN3O4.H2O/c2*1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21;/h2*7-8,10H,3-6,9H2,1-2H3,(H,24,25);1H2/t2*10-;/m00./s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H20FN3O4

                    

                    
                    

                        
HBD / HBA

                        
1 / 8

                    

                    
                    

                        
Liaisons Rotatives

                        
2

                    

                    
                    
                    

                        
Atomes Lourds

                        
26

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Foire aux questions

                

                    
                    

                        
                        

                            
A broad-spectrum fluoroquinolone antibiotic used to treat respiratory tract infections, urinary tract infections, skin infections, and certain cases of anthrax. It works by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Fluoroquinolone antibiotic inhibiting bacterial DNA gyrase and topoisomerase IV.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Levofloxacin: Half-life: 6-8 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Levofloxacin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Amoxicillin
                            Small molecule
                        
                        
                        
                            Azithromycin
                            Small molecule
                        
                        
                        
                            Ciprofloxacin
                            Small molecule
                        
                        
                        
                            Doxycycline
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL5315124.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 149096.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Avertissement médical

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.